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Weeks 5 through 8: optimization phase Increase to 20 to 22.5 units daily (4.0 to 4.5mg total)
This is why many people turn to supplementation
These data were first presented by Amanda Johnson, MD, Mayo Clinic, Rochester, Minnesota, at the 2026 Crohns and Colitis Congress on Friday, January 23, 2026, in Las Vegas, Nevada
Studies show that weight regain is common within 12 months of discontinuing GLP-1 therapy, with many individuals regaining two-thirds of what they lost (PubMed)
If youre in a significant calorie deficit due to using a GLP-1, youll also want to prioritize protein to help prevent muscle loss
Consequently, this could improve cellular function by regulating cellular events, such as cytokine production, cell proliferation, synthesis of DNA and proteins, etc
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